Medicare
NC + SC
Palmetto GBA processes Part A and Part B claims for both states under Jurisdiction M. Coverage determinations, appeal windows and the eServices portal are identical whether the visit happened in Asheville or Aiken.
What changes is which Medicare Advantage plan sits on top of it.
Medicare Advantage
NC + SC
Medicare Advantage enrollment is common throughout both states, and plan mix differs county by county. Humana, UnitedHealthcare and Blue Cross plans dominate different pockets of each state, each with its own prior authorization list and its own timely filing clock.
Practices need payer-specific workflows that account for these differences before claims are submitted.
NC Medicaid
NC
Five Standard Plans, four regional Tailored Plans for behavioral health and I/DD, the EBCI Tribal Option, and NC Medicaid Direct for anyone not yet assigned to a plan.
Five different payer IDs and five different clean-claim windows, sitting under one beneficiary.
SC Medicaid
SC
Healthy Connections Medicaid still runs largely fee-for-service outside its five contracted MCOs, and the January 2026 carve-in moved a new slice of adult and nursing-facility claims into managed care.
Two systems, two sets of authorization rules, one program name.
TRICARE and VA
NC + SC
Fort Liberty, Fort Jackson, Marine Corps Air Station Beaufort and Shaw Air Force Base put a large TRICARE population within reach of Carolinas practices.
TRICARE East claims route through Humana Military, on a timely filing clock that runs separately from Medicare or Medicaid.
Multi-location practices
NC + SC
Groups with a clinic in Charlotte and one in Rock Hill, or in Wilmington and Myrtle Beach, are running two Medicaid programs, two fee schedules and two provider enrollment files under a single tax ID.
Nothing about that setup is automatic.